By Stephen Daniells, 26-Apr-2012
Related topics: Antioxidants, carotenoids, Phytochemicals, plant extracts, Cardiovascular health, Research
The trial, claimed to be found that levels of C-reactive protein (CRP), a well-established marker of inflammation, fell by 26%, report researchers in the .
The study was performed in people at high risk of cardiovascular disease (CVD) and the participants were also receiving statins. However, people in the placebo group did not exhibit the same beneficial reductions in inflammatory markers. wrote researchers, led by Juan Carlos Espin, PhD, from the Research Group on Quality, Safety, and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia.
Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992
by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.
Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.
The Spanish researchers recruited 75 people receiving statins as primary prevention of CVD to participate in their triple-blinded, randomized, parallel, dose-response, placebo-controlled, follow-up trial.
Participants received either a resveratrol-rich grape supplement (resveratrol 8 mg), a conventional resveratrol-free grape supplement resveratrol, or placebo (maltodextrin) for six months, and then double the dose for the next six months.
Results showed a significant decrease in CRP levels in the resveratrol-rich grape supplement only, with no changes in the other two groups. In addition, other markers of inflammation decreased, including tumor necrosis factor-alpha (TNF-alpha, 19.8% decrease), and plasminogen activator inhibitor type 1 (PAI-1, 16.8% decrease).
On the other hand, the resveratrol-rich grape supplement also increased levels of the anti-inflammatory interleukin- 10 by 20%, while no such changes were observed in the other groups. wrote the researchers.they concluded.
Source:Published online ahead of print, doi: 10.1016/j.amjcard.2012.03.030
From :http://www.nutraingredients.com/Product-Categories/Phytochemicals-plant-extracts/Resveratrolrich-grape-extract-shows-heart-health-benefits-Human-data/?c=IvT2lLjyjtQxL5jEde%2FLjA%3D3D&utm_source=Newsletter_Product&utm_medium=email&utm_campaign=Newsletter%2BProduct